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URN: urn:nbn:de:hbz:467-13311
URL: http://dokumentix.ub.uni-siegen.de/opus/volltexte/2018/1331/


Failure to replicate the association between fractional anisotropy and the serotonin transporter gene (5-HTTLPR, rs25531)

Klucken, Tim ; Tapia León, Isabell ; Blecker, Carlo ; Kruse, Onno ; Stalder, Tobias ; Stark, Rudolf

Originalveröffentlichung: (2018) Frontiers in behavioral neuroscience ; April 2018, Volume 12, Article 80. - DOI: 10.3389/fnbeh.2018.00080
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SWD-Schlagwörter: Substantia alba , Nervenfaserbündel , Anisotropie , Serotonin , Diffusionsgewichtete Magnetresonanztomografie
Freie Schlagwörter (Englisch): White matter microstructure integrity , Diffusion tensor imaging , Serotonin , Connectivity , Uncinate fasciculus
Institut: (ohne Institutsbezeichnung)
DDC-Sachgruppe: Psychologie
GHBS-Notationen: HRC = Psychophysik. Physiologische Psychologie. Neuropsychologie. Psychobiologie. Gestalttheorie
VYE = Neurologie. Neuroanatomie
Dokumentart: Wissenschaftlicher Artikel
Sprache: Englisch
Erstellungsjahr: 2018
Publikationsdatum: 19.06.2018
Bemerkung: Finanziert aus dem DFG-geförderten Open-Access-Publikationsfonds der Universität Siegen für Zeitschriftenartikel
Kurzfassung auf Englisch: Recent work underlines the importance of alterations in white matter (e.g., measured by fractional anisotropy (FA)) as a neural vulnerability marker for psychiatric disorders. In this context, the uncinate fasciculus (UF), which connects the limbic system with prefrontal areas, has repeatedly been linked to psychiatric disorders, fear processing, and anxietyrelated traits. Individual differences in FA may partly be genetically determined. Variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) is a particularly promising candidate in this context, which has been linked to psychiatric disorders as well as to limbic and prefrontal reactivity. However, findings on the association between the 5-HTTLPR and FA within the UF-tract have been heterogeneous. The present study investigated this relationship and extended previous work by considering different genetic classification approaches as well as sex effects in a human sample (n = 114). All participants were genotyped for the 5-HTTLPR and the rs25531 polymorphism. As a main result, we did not find any significant relationship between the 5-HTTLPR and FA in the UF-tract although power analyses showed an adequate power. In addition, genotype effects were neither found when different classification approaches were used nor when analyses were carried out in males or females only. The present findings suggest that the association of the 5-HTTLPR and FA seems to be a more labile phenomenon than previously assumed.
Possible explanations and limitations are discussed.
Lizenz: Veröffentlichtungsvertrag